Cardium Therapeutics, an asset-based health sciences and regenerative medicine company, today highlighted the publication, “Mechanistic, Technical, and Clinical Perspectives in Therapeutic Stimulation of Coronary Collateral Development by Angiogenic Growth Factors,” authored by Gabor M Rubanyi, M.D., Ph.D., Cardium’s chief scientific officer in the April issue of Molecular Therapy.
The publication frameworks the mechanistic basis of adaptive coronary collateral growth, the biological processes to be targeted by therapeutic angiogenesis, and the optimization of clinical trial designs, including information on designating appropriate clinical trial endpoints, selecting patients who are likely responders to therapeutic stimulation of collateral development, and potential genetic and molecular markers in patient screening.
Dr. Rubanyi also summarizes the knowledge gained in the last 15 years of pre-clinical and clinical research and development initiatives in the field of therapeutic angiogenesis using growth factor proteins and genes.
“I also described in some detail the specific insights that our team, first at Schering AG (now part of Bayer Healthcare) and now at Cardium, has gained in the course of the development of Generx, one of the most advanced therapeutic angiogenesis product candidates,” Dr. Rubanyi stated in the press release. “These lessons have been invaluable and they have been incorporated into the trial design of the Generx ASPIRE pivotal phase 3 clinical study now underway at several leading cardiovascular centers in the Russian Federation.”
Generx is Cardium’s interventional cardiology-focused product candidate currently in development as a non-surgical option for the treatment of a medical condition termed cardiac microvascular insufficiency (CMI).
The abstract of the publication is available at www.nature.com/mt/journal/v21/n4/abs/mt201313a.html (membership required for full viewing). The company will mail the full article to interested parties upon request by contacting Cardium at 858-436-1000.
For more information visit www.cardiumthx.com
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